Abelmoschus esculentus (L.) Moench Pod Extract Revealed Antagonistic Effect against the Synergistic Antidiabetic Activity of Metformin and Acarbose upon Concomitant Administration in Glucose-Induced Hyperglycemic Mice

Abelmoschus esculentus (L.) Moench, commonly known as okra, is one of the most widely used vegetable crops currently for diabetes treatment well. It thought that large amount soluble dietary fibers present in okra responsible slowing absorption glucose from gut. However, its role concomitant administration with prescribed medications, including metformin (MET) and acarbose (ACR) diabetes, unclear. Therefore, this study assessed effect A. pod extract (AEE) administered concomitantly MET ACR glucose-induced hyperglycemic mice model. The AEE was prepared using green pods. In experiment, each male Swiss Webster mouse a 2.5 gm/kg/BW dose via gastric lavage to induce hyperglycemia. experimental animals were divided into five groups: (i) negative control, (ii) positive (iii) only, (iv) ACR, (v) MET, AEE. orally doses 150 mg/kg/BW, 15 0.2 mL/kg/BW, respectively. We found only combination reduced levels significantly (p < 0.01) compared control. On other hand, when simultaneously, synergistic antihyperglycemic action diminished. After min, blood level 4.50 ± 0.189 mmol/L 6.58 0.172 (v). This suggests taking concurrently would reduce effectiveness antidiabetic drugs; thereby, these agents not recommended. provides an essential basis decision-making about consumption conventional medicine. Further required find molecular insight drug interactions therapy medicinal plants diabetes.